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Prophylaxis of German Measles with Immune Serum Globulin

Robert F. Korns
The Journal of Infectious Diseases
Vol. 90, No. 2 (Mar. - Apr., 1952), pp. 183-189
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30094109
Page Count: 7
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Prophylaxis of German Measles with Immune Serum Globulin
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Abstract

1. Evidence has been presented demonstrating the prophylactic value of a particular lot of immune serum globulin in the prevention of German measles. During the period three to 26 days after receiving 0.1 ml per pound of body weight of this lot, only nine cases occurred among 45 immunized persons (20.0%), as compared to 35 cases among 60 comparable controls (58.4%). The difference in attack rate is highly significant statistically. 2. One other lot of immune globulin failed to prevent the disease, while a third lot showed only slight protection. It seems likely that these conflicting results are a reflection of the relative potency of German measles antibodies in different lots of immune serum globulin. For the prevention of German measles in the exposed pregnant female, it seems essential that a known potent product be utilized, possibly immune serum globulin made from convalescent German measles serum. In the absence of such material there still may be merit to using the ordinary immune serum globulin for such protection.

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