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The Association in Young Mice of Intestinal Inflammation and the Loss of Adult Worms following an Initial Infection with Trichinella spiralis

John E. Larsh Jr., George J. Race and William B. Jeffries
The Journal of Infectious Diseases
Vol. 99, No. 1 (Jul. - Aug., 1956), pp. 63-71
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30098271
Page Count: 9
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The Association in Young Mice of Intestinal Inflammation and the Loss of Adult Worms following an Initial Infection with Trichinella spiralis
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Abstract

Young mice given an initial infection with Trichinella spiralis lost a significant number of adult worms between 15 and 17 days after infection. Related to this loss of worms was the development in the intestinal tissue of a characteristic cellular reaction, which reached its peak at 11 days after infection. Evidence is presented to show that this reaction, differing only in the time of its initiation and in degree from that in old mice given one infection and in those strongly immunized by prior infections, is a manifestation of acquired immunity. Therefore, these results indicate that following initial infection of young and old mice the slower elimination of adult T. spiralis from the young mice is due to their inability to develop acquired immunity as rapidly as the old mice.

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