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Studies on Protection against Experimental Tularemia in Mice: I. Altered Susceptibility of White Mice to Tularemia following Hemophilus pertussis Vaccination

Lolita Pannell
The Journal of Infectious Diseases
Vol. 102, No. 2 (Mar. - Apr., 1958), pp. 162-166
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30098394
Page Count: 5
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Studies on Protection against Experimental Tularemia in Mice: I. Altered Susceptibility of White Mice to Tularemia following Hemophilus pertussis Vaccination
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Abstract

An alteration in susceptibility and resistance of white mice to tularemia following vaccination with Hemophilus pertussis was observed. The effect of previous vaccination or simultaneous inclusion of the vaccine was estimated by observing the mortality rates in infected Swiss-Webster mice. It was found that pretreatment with H. pertussis vaccine increased their resistance to a challenge of approximately 100 LD50 of a moderately virulent strain. Simultaneous inoculation of H. pertussis vaccine and living Bact. tularense increased the susceptibility to infection with the latter. The combination of H. pertussis with Bad. tularense vaccine improved the efficacy of the latter to low challenge doses of tularemia. The value of H. pertussis vaccine as an adjuvant has been discussed.

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