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Studies on Immunity to Staphylococcal Infection in Mice: I. Effect of Dosage, Viability, and Interval between Immunization and Challenge on Resistance to Infection following Injection of Whole Cell Vaccines

Richard D. Ekstedt
The Journal of Infectious Diseases
Vol. 112, No. 2 (Mar. - Apr., 1963), pp. 143-151
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30099445
Page Count: 9
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Studies on Immunity to Staphylococcal Infection in Mice: I. Effect of Dosage, Viability, and Interval between Immunization and Challenge on Resistance to Infection following Injection of Whole Cell Vaccines
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Abstract

Using a single intraperitoneal immunizing injection of $10^7$ living staphylococci or $10^9$ heat- or formalin-killed organisms, mice of the CF-1 strain can be actively immunized to challenge with the homologous strain of staphylococcus in saline suspension. The increased resistance develops maximally at 2 weeks after vaccination and diminishes to near preimmunization levels when the interval between immunization and challenge is prolonged to 4 weeks. In vitro study of pooled sera taken from animals at weekly intervals following vaccination showed no direct correlation between agglutinating antibody or α-antitoxin and protection as demonstrated by direct challenge. When studied for their ability to enhance phagocytic-bactericidal activity of normal mouse blood, these sera did show a correlation with the protection data. The protection appears to be specific in that immunization with another strain of staphylococcus or with a streptococcus did not result in any demonstrable increase in resistance to challenge infections. The factors involved in the mechanism of resistance to staphylococcal infection are discussed.

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