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The Influence of Environmental Temperature on the Course of Experimental Herpes Simplex Infection

J. R. Schmidt and A. F. Rasmussen Jr.
The Journal of Infectious Diseases
Vol. 107, No. 3 (Nov. - Dec., 1960), pp. 356-360
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30101898
Page Count: 5
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The Influence of Environmental Temperature on the Course of Experimental Herpes Simplex Infection
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Abstract

Mice were found to be more resistant to infection with herpes simplex virus when maintained at 37 C than at 24 C. The lower percentage mortality of mice held at 3 7 C was attributed to a lower concentration of virus in the brains of these animals. No difference was observed in the percentage mortality of herpes-infected mice kept a 2 C and 24 C. The immune response of mice to a formalinized herpes vaccine was unaffected by a high environmental temperature; i.e., the rate of development of protective immunity and the degree of protection attained were identical in mice maintained at 24 C and 37 C during the immunization period.

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