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Parainfluenza Type 3 Virus Infection in Hamsters: Virologic, Serologic, and Pathologic Studies
D. A. Buthala and M. G. Soret
The Journal of Infectious Diseases
Vol. 114, No. 3 (Jun., 1964), pp. 226-234
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30101940
Page Count: 9
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Parainfluenza type 3 virus infection of hamsters can be accomplished by several routes of inoculation, as evidenced by serologic response. I ntranasal or intratracheal administration gave the most consistent serologic and histopathologic data. Following infection of hamsters with the virus, the epithelial cells of the anterior turbinates showed focal necrotic lesions. Simultaneously, similar alterations were observed in the epithelial lining of the major bronchioles. Peribronchiolar and perivascular leukocytic infiltration with edematous changes in submucosa were common. Epithelial cell degeneration with desquamation occurred from the 3rd through the 7th day of infection. Repair of the cellular damage was rapid after the 7th day, with a return to normal by the 13th to the 15th day. Virus recovery from infected lungs could not be accomplished until after 12 to 14 hours following infection, after which time the virus titer rose rapidly to reach a maximum at 24 to 48 hours. After the 7th or 8th day no virus was recoverable. Neutralizing and complement-fixing antibodies were not detected until the 7th or 8th day, reaching a peak titer by the 15th day.
The Journal of Infectious Diseases © 1964 Oxford University Press