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Specific and Nonspecific Passive Immunity in Infant Rabbit Cholera

J. D. Gillmore, P. M. Versage and R. A. Phillips
The Journal of Infectious Diseases
Vol. 116, No. 3 (Jun., 1966), pp. 313-318
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30102091
Page Count: 6
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Specific and Nonspecific Passive Immunity in Infant Rabbit Cholera
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Abstract

A typical profuse and fatal diarrheal disease was produced in infant rabbits by intraintestinal challenge with small numbers of an egg and rabbit-passed strain of Vibrio cholerae. Passive serum protection was demonstrated when a single 0.5-ml injection of homologous OH antisera to live vibrios was administered intraperitoneally 48 to 72 hours before challenge. When a heterologous rabbit-passed Inaba strain was used for antisera production, passive protection was still obtained but decreased from 84 to 70%. Experiments with heterologous OH antisera to live Ogawa vibrios gave only 13% protection against Inaba challenge. All live vibrio immunizations induced a strong agglutinin and vibriocidal response in the immunized animals. Survival of infant rabbits that received normal rabbit sera as controls was 9%, while only 3% of the controls that received normal saline survived. Hyperimmune sera obtained from rabbits immunized in the same manner with commercial typhoid-paratyphoid vaccine gave protection in 28% of the animals challenged, whereas rabbits that received sera from animals immunized with tetanus toxoid all succumbed to infection. Both antisera had very low agglutinin and vibriocidal titers. Hyperimmune antisera prepared with cell-free mucinase(s) preparations gave 20% protection, although high agglutinin and vibriocidal titers were produced by the immunizations. Passive protective activity demonstrated with hyperimmune sera prepared with other Gram-negative organisms and cell-free vibrio products indicates the necessity for proper selection of placebo or control inoculations to be utilized in laboratory or cholera vaccine field studies.

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