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Attempted Isolation of Hepatitis Viruses in Marmosets

Wade P. Parks and Joseph L. Melnick
The Journal of Infectious Diseases
Vol. 120, No. 5 (Nov., 1969), pp. 539-547
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30102203
Page Count: 9
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Attempted Isolation of Hepatitis Viruses in Marmosets
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Abstract

Inoculation of human hepatitis materials into cotton-topped marmosets was associated with the development of elevated serum transaminase and histologic changes; however, the proportion of marmosets demonstrating such changes was not significantly greater than that observed in a variety of control marmosets. Transmission studies demonstrated the presence of an infectious agent in the sera of both test and control animals with equal frequency. The development of elevated serum transaminase and histologic hepatic changes in inoculated and uninoculated marmosets was also associated with the development of resistance to challenge with the Barker strain of marmosets hepatitis. Conversely, stains recovered from marmosets failed to produce hepatitis in marmosets resistant to the Barker strain. The present data suggest an indigenous origin for the marmoset hepatitis virus, and militate against the use of the marmoset as a laboratory animal for the isolation of strains of human hepatitis virus.

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