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Gentamicin: Laboratory and Clinical Experience in Mexico

E. Escárzaga
The Journal of Infectious Diseases
Vol. 119, No. 4/5, International Symposium on Gentamicin: A New Aminoglycoside Antibiotic (Apr. - May, 1969), pp. 443-447
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30102380
Page Count: 5
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Gentamicin: Laboratory and Clinical Experience in Mexico
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Abstract

This paper briefly describes 6 studies carried out with gentamicin in Mexico; the first one deals with in vitro susceptibility of 931 isolates. The authors found the drug to have good activity. In the second study, gentamicin was used in 44 patients with different types of infections, using 0.8 mg/kilogram per day. Side effects from the treatment with gentamicin were carefully observed. Only 6 cases (13.6%) were considered to be failures. Side effects consisting of bilateral loss of hearing acuity, moderate dizziness, nausea, and vomiting were noticed in 1 patient but cleared completely 5 days after the suspension of treatment. The third trial was done with gentamicin given orally for the treatment of acute children's diarrhea. The results were not conclusive since it seemed that a lower dose gave better clinical and bacteriological results than a higher one. Moreover, only 23 children were included in the trial. The fourth trial was made in 50 patients, using 2.4 mg/kilogram as the daily dose. All these patients were cured, and no side effects were noted. In the fifth study the daily dose was 3 mg/kilogram per day given to 30 patients, most of them with severe infections. Blood levels of gentamicin were determined in 12 of the 30 patients. There were 4 clinical and 5 bacteriological failures, but no side effects were noted. The final trial involved 81 patients with non-obstructive urinary tract infections treated with various drugs, 20 of the patients receiving gentamicin, 1 mg/kilogram per day. In this study, the action of gentamicin was compared with 7 other antibiotics. Gentamicin seemed to give the best results.

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