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Temperature-Sensitive Mutants of Influenza Virus. V. Evaluation in Man of an Additional ts Recombinant Virus with a 39 C Shutoff Temperature

Brian R. Murphy, David S. Hodes, Sandra R. Nusinoff, Susan Spring-Stewart, Eveline L. Tierney and Robert M. Chanock
The Journal of Infectious Diseases
Vol. 130, No. 2 (Aug., 1974), pp. 144-149
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30106167
Page Count: 6
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Temperature-Sensitive Mutants of Influenza Virus. V. Evaluation in Man of an Additional ts Recombinant Virus with a 39 C Shutoff Temperature
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Abstract

Two recombinant temperature-sensitive (ts) influenza A/Hong Kong/68 (H3N2) viruses that exhibited a marked decrease in efficiency of plaque formation at 39 C but that had lesions in different cistrons of the influenza A virus genome were evaluated for level of virulence in man. Both viruses retained the capacity to cause mild influenzal illness that was less severe than that caused by wild-type virus but more severe than that of the candidate influenza A/HK/68-ts-1[E] vaccine virus. These studies indicated that two viruses with similar temperature sensitivity but different genetic lesions had a similar level of attenuation for man. This observation supports the suggestion that it is the degree of defectiveness, i.e., temperature sensitivity, of a mutant virus and not the loss of a specific biochemical function that is the determinant of attenuation of these viruses for man.

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