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Receptor-Mediated Clearance of Aspergillus Galactomannan

John E. Bennett, Marc M. Friedman and Bertrand Dupont
The Journal of Infectious Diseases
Vol. 155, No. 5 (May, 1987), pp. 1005-1010
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30106235
Page Count: 6
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Receptor-Mediated Clearance of Aspergillus Galactomannan
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Abstract

The fate of radiolabeled Aspergillus fumigatus galactomannan was studied after intravenous injection into rabbits and rats. At 1 hr, the liver contained 35% of the injected dose in rabbits and 30% in rats. Excretion of galactomannan into the urine, measured in rabbits, was another major catabolic route and accounted for 35% of the dose by 24 hr. Immunization of rabbits increased hepatic uptake and decreased urinary excretion. Hepatic uptake in unimmunized rats could be decreased by Saccharomyces cerevisiae mannan, α-methylmannoside, and N-acetylglucosamine, known inhibitors of the macrophage mannose receptor. Autoradiography showed hepatic radiolabeled galactomannan to be concentrated in Kupf fer cells, which express the mannosyl receptor for glycoproteins. Macrophage mannosyl receptors may constitute a general mechanism for clearing fungal man-nans from the bloodstream.

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