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Vaccinated Children Get Milder Measles Infection: A Community Study from Guinea-Bissau
Peter Aaby, Jette Bukh, Jørgen Leerhøy, Ida Maria Lisse, Carl H. Mordhorst and Ib Rode Pedersen
The Journal of Infectious Diseases
Vol. 154, No. 5 (Nov., 1986), pp. 858-863
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30106702
Page Count: 6
You can always find the topics here!Topics: Children, Measles, Vaccination, Infections, Mortality, Antibodies, Child development, Immunization, Epidemiology, Child nutrition
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We studied the occurence of measles in vaccinated children from an urban area of Guinea-Bissau where measles causes high mortality. Vaccinated children who developed measles required more-intense exposure to become infected (they had a higher ratio of secondary cases [infected in the house] to index cases [infected outside the house]), had a lower mortality among secondary cases, and were less infectious (they generated fewer secondary cases than did unvaccinated children with measles). The attack rate among vaccinated children was significantly higher in households in which someone died of measles. Both severity of infection and development of measles in vaccinated children were related to intensity of exposure. Vaccine efficacy was 72%, and 33% of cases occured among vaccinated children; however, most mothers remained confident that vaccinated children get milder measles. Moreover, there was significantly greater vaccination coverage among younger siblings of vaccinated children who had contracted measles than among other children in the community.
The Journal of Infectious Diseases © 1986 Oxford University Press