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Design of Aromatic Inhibitors of Influenza Virus Neuraminidase

Ming Luo, Gillian M. Air and Wayne J. Brouillette
The Journal of Infectious Diseases
Vol. 176, Supplement 1. Pandemic Influenza: Confronting a Re-Emergent Threat (Aug., 1997), pp. S62-S65
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30106839
Page Count: 4
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Design of Aromatic Inhibitors of Influenza Virus Neuraminidase
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Abstract

Structure-based drug design, a terminology used to describe rational drug design by complementing the structure, spatially and chemically, of the target macromolecule, is rapidly developing as one of the innovative approaches to drug discovery. A growing volume of protein structure data and new techniques of protein structure determination make this all possible. The method of structure-based drug design and a specific example of the design of influenza virus neuraminidase is briefly presented. A whole new class of influenza virus neuraminidase inhibitors has been designed that can potentially be developed as antiinfluenza drugs.

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