You are not currently logged in.
Access your personal account or get JSTOR access through your library or other institution:
Effect of Enterotoxins of Vibrio cholerae, Escherichia coli, and Shigella dysenteriae Type 1 on Fluid and Electrolyte Transport in the Colon
Mark Donowitz and Henry J. Binder
The Journal of Infectious Diseases
Vol. 134, No. 2 (Aug., 1976), pp. 135-143
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30106991
Page Count: 9
Preview not available
Experiments were designed to determine whether the enterotoxins of Vibrio cholerae, Escherichia coli, and Shigella dysenteriae type 1 alter the movement of fluid and electrolytes in the rat cecum. Net secretion of water and sodium were observed after incubation of 1.67 X 10⁻⁵ μg of purified cholera toxin (choleragen)/ml for 18 hr or of 50 μg/ml for 3 hr. The effect of choleragen on cecal transport of water and electrolytes was related to the dose. In addition, choleragen increased cecal mucosal content of adenosine 3′:5′-cyclic phosphate but did not alter the histology of the cecum. The results demonstrate that the colon responds to choleragen in a manner similar to that of other tissues. In contrast, the enterotoxins of both E. coli and S. dysenteriae type 1 failed to affect cecal transport of water and electrolytes. These observations may explain several phenomena associated with the diarrhea produced by bacterial enterotoxins.
The Journal of Infectious Diseases © 1976 Oxford University Press