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Antibody Response of Young Adults to Experimental Influenza A/New Jersey/76 Virus Vaccines

Gordon Meiklejohn, Theodore C. Eickhoff and Pat Graves
The Journal of Infectious Diseases
Vol. 136, Supplement. Clinical Studies of Influenza Vaccines: 1976 (Dec., 1977), pp. S456-S459
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30107514
Page Count: 4
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Antibody Response of Young Adults to Experimental Influenza A/New Jersey/76 Virus Vaccines
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Abstract

In military personnel aged 17-25 years, only one of four experimental influenza A/New Jersey/76 virus vaccines produced a satisfactory hemagglutination-inhibiting (HAI) antibody response when a dose of 200 chick cell-agglutinating (CCA) units was used. A second injection of 400 CCA units of vaccine caused seroconversion in all persons. Although an early comparison of experimental split-product and whole-virus vaccines suggested that the former were relatively ineffective, a later comparison with different lots of the vaccines showed no difference between vaccines of these two types. The influenza A/NJ/76 virus vaccine evoked a high HAI antibody response to influenza A/PR/8/34 (HON1) virus but not to H1N1 or H3N2 strains.

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