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Modification of an Outbreak of Influenza in Tecumseh, Michigan by Vaccination of Schoolchildren
Arnold S. Monto, Fred M. Davenport, John A. Napier and Thomas Francis Jr.
The Journal of Infectious Diseases
Vol. 122, No. 1/2 (Jul. - Aug., 1970), pp. 16-25
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30108280
Page Count: 10
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Inactive vaccine against the Hong Kong variant of influenza was offered to the schoolchildren of Tecumseh, Michigan, a community that has been under study since 1959. The aim was to modify the course of the expected outbreak of influenza in the entire population of the area. More than 85% of the schoolchildren were vaccinated. Systemic reactions were rare. The reciprocal geometric mean titer after vaccination was 61. Surveillance of respiratory illness was underway in Tecumseh and in the neighboring community of Adrian, Michigan. In the outbreak of Hong Kong influenza that occurred in the weeks after vaccination, there was 3.0 times more illness in Adrian than in Tecumseh. The protection from illness was not limited to the schoolchildren, since rates of illness in Tecumseh were also lower for adults and younger children than those for Adrian. The difference between Adrian and Tecumseh was not an isolated finding, since 2 other communities in Michigan also had higher rates of illness. An outbreak of Type B influenza began 1 month after the Hong Kong outbreak in both Tecumseh and Adrian. The vaccine used in Tecumseh contained only the Hong Kong variant, and the rates of illness for the 2 communities during the period of influenza B were almost identical. This confirmed further that the difference between the rates of illness in the period of Hong Kong influenza was produced by the use of the vaccine.
The Journal of Infectious Diseases © 1970 Oxford University Press