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Carbenicillin: Chemistry and Mode of Action

Kenneth Butler, Arthur R. English, Verne A. Ray and A. E. Timreck
The Journal of Infectious Diseases
Vol. 122, Supplement. Symposium on Carbenicillin: A Clinical Profile (Sep., 1970), pp. S1-S8
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30108303
Page Count: 8
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Carbenicillin: Chemistry and Mode of Action
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Abstract

Carbenicillin is a new semi-synthetic penicillin clinically effective against a broad spectrum of bacterial infections. Laboratory data suggest that carbenicillin should be especially useful in the treatment of infections of the urinary tract. It is effective against a wider range of gram-negative bacteria than are existing penicillins, and it is unique in its in-vitro and in-vivo activity against Proteus and Pseudomonas species. Such activity appears to be a consequence of transport phenomena since the intrinsic activity of carbenicillin is comparable to that of ampicillin. An equilibrium mixture of the 2 diastereoisomers has demonstrated biologic activity equivalent to purified preparations of either isomer.

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