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Clinical and Microbiologic Studies of Carbenicillin
Dan Michaeli and Louis Weinstein
The Journal of Infectious Diseases
Vol. 122, Supplement. Symposium on Carbenicillin: A Clinical Profile (Sep., 1970), pp. S90-S95
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30108319
Page Count: 6
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Eleven patients received carbenicillin for treatment of infections caused by Pseudomonas (9 persons), Pseudomonas and Enterobacter (1), and Serratia marcescens (1). In all cases, host defense functions were normal. Superinfection was responsible for the infection in 3 cases. Four patients were cured, and 3 died of their infection. The rate of resistant mutation was established for Pseudomonas. It occurs in 10⁶-10⁸ organisms and is related to the minimal inhibitory concentration (MIC) of carbenicillin for the given strain. The combination of carbenicillin (100 μg/ml) and gentamicin (4 μg/ml) was found to be synergistic and can inhibit growth of a resistant strain of Pseudomonas.
The Journal of Infectious Diseases © 1970 Oxford University Press