Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Clinical and Microbiologic Studies of Carbenicillin

Dan Michaeli and Louis Weinstein
The Journal of Infectious Diseases
Vol. 122, Supplement. Symposium on Carbenicillin: A Clinical Profile (Sep., 1970), pp. S90-S95
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30108319
Page Count: 6
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Clinical and Microbiologic Studies of Carbenicillin
Preview not available

Abstract

Eleven patients received carbenicillin for treatment of infections caused by Pseudomonas (9 persons), Pseudomonas and Enterobacter (1), and Serratia marcescens (1). In all cases, host defense functions were normal. Superinfection was responsible for the infection in 3 cases. Four patients were cured, and 3 died of their infection. The rate of resistant mutation was established for Pseudomonas. It occurs in 10⁶-10⁸ organisms and is related to the minimal inhibitory concentration (MIC) of carbenicillin for the given strain. The combination of carbenicillin (100 μg/ml) and gentamicin (4 μg/ml) was found to be synergistic and can inhibit growth of a resistant strain of Pseudomonas.

Page Thumbnails

  • Thumbnail: Page 
S90
    S90
  • Thumbnail: Page 
S91
    S91
  • Thumbnail: Page 
S92
    S92
  • Thumbnail: Page 
S93
    S93
  • Thumbnail: Page 
S94
    S94
  • Thumbnail: Page 
S95
    S95