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Correlated Studies of a Recombinant Influenza-Virus Vaccine. IV. Protection against Naturally Occurring Influenza in Military Trainees

Albert Leibovitz, Raymond L. Coultrip, Edwin D. Kilbourne, Llewellyn J. Legters, Creed D. Smith, James Chin and Jerome L. Schulman
The Journal of Infectious Diseases
Vol. 124, No. 5 (Nov., 1971), pp. 481-487
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30108467
Page Count: 7
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Correlated Studies of a Recombinant Influenza-Virus Vaccine. IV. Protection against Naturally Occurring Influenza in Military Trainees
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Abstract

An inactivated influenza vaccine made from a recombinant virus, X-31, derived from HK/Aichi/68 and $A_{0}7PR8/34$ influenza viruses, was tested in a population of 9,616 military trainees at Fort Ord, California, during the winter and spring of 1970. Of the population, 1,682 (1896) were immunized with 556 chick-cell-agglutinating units of X-31 vaccine and 7,934 (82%) served as controls. In a smaller subgroup in which antigenicity of the vaccine was studied, 7196 of those vaccinated exhibited a significant hemagglutination-inhibition antibody response. During the period of surveillance, Hong Kong influenza was diagnosed in 102 (1.396) of 7,934 control subjects. Only five cases (0.396) were detected in 1,682 subjects previously given X-31 vaccine. The calculated protection ratio was 4.3, and the reduction in clinical infection was 7396. These studies demonstrate the feasibility of producing an effective vaccine from a recombinant virus. This protection compares favorably with that afforded by earlier standard influenza vaccines.

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