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Increased Antibody to Herpes Simplex Virus in Patients with Nasopharyngeal Cancer
Erskine L. Palmer, Paul M. Feorino and Mary Lane Martin
The Journal of Infectious Diseases
Vol. 126, No. 2 (Aug., 1972), pp. 186-188
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30108597
Page Count: 3
You can always find the topics here!Topics: Simplexvirus, Antibodies, Antigens, Infections, Capsid, Epstein Barr virus infections, Viruses, Human herpesvirus 4, Burkitt lymphoma, Cancer
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Sera from patients with nasopharyngeal cancer, Burkitt's lymphoma, and primary infection with herpes simplex virus, and sera from controls were tested for antibodies to herpes simplex virus by the complement-fixation test and for antibodies to Epstein-Barr virus by fluorescent-antibody test. Sera from patients with nasopharyngeal cancer contained elevated levels of antibody to both herpes simplex and Epstein-Barr viruses, whereas sera from patients with Burkitt's lymphoma contained elevated levels of antibody to Epstein-Barr virus only. Titers of antibodies to subunits of herpes simplex virus in the sera of patients with nasopharyngeal cancer were higher than those in control sera. The levels of antibody were markedly similar to those in convalescent-phase sera of individuals with recent primary infection with herpes simplex virus. The antibody profiles of some patients with nasopharyngeal cancer were consistent with reactivated, latent infection with herpes simplex virus.
The Journal of Infectious Diseases © 1972 Oxford University Press