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GB Virus C Infection in Patients with Primary Antibody Deficiency

A. Morris, A. D. B. Webster, D. Brown, T. J. Harrison and G. Dusheiko
The Journal of Infectious Diseases
Vol. 177, No. 6 (Jun., 1998), pp. 1719-1722
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30108898
Page Count: 4
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GB Virus C Infection in Patients with Primary Antibody Deficiency
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Abstract

Sera from 77 patients with common variable immunodeficiency (CVID) were tested for GB virus C (GBV-C) RNA, because they are prone to unexplained chronic hepatitis, and from 28 patients with X-linked agammaglobulinemia (XLA) who have a similar primary antibody deficiency but are not prone to hepatitis. Eight CVID and 8 XLA patients were positive; 6 positive CVID and 3 XLA patients had abnormal liver enzymes, explained in 3 by either hepatitis B or C virus infection. Most patients tested had antibodies to the E2 antigen of GBV-C, apparently passively acquired from their immunoglobulin therapy. The high prevalence of GBV-C viremia in CVID and XLA patients is probably explained by their long-term exposure to blood products. Our data indicate that GBVC does not cause chronic hepatitis in immunocompromised XLA patients and is not the cause of chronic non-B or -C hepatitis in the majority of CVID patients.

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