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Clinical Experience with Cefamandole for Treatment of Serious Bone and Joint Infections

Louise R. Levine and Elizabeth McCain
The Journal of Infectious Diseases
Vol. 137, Supplement. Symposium on Cefamandole (May, 1978), pp. S119-S124
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30108964
Page Count: 6
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Clinical Experience with Cefamandole for Treatment of Serious Bone and Joint Infections
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Abstract

The safety and efficacy of treatment with cefamandole were evaluated in 30 patients (from 18 institutions) with serious bone and joint infections. Five of the subjects were children. The antibiotic was given intramuscularly or intravenously in doses ranging from 2 to 12 g daily for five to 44 days. Twenty-six of the 30 patients responded satisfactorily. Fourteen of the fifteen infections due to Staphylococcus aureus were among the successful cases. Other pathogens were streptococci, Escherichia coli, Proteus mirabilis, and Bacteroides fragilis. The drug was well tolerated in patients in this series. Studies indicated that cefamandole penetrated the bones and joints. Further investigation of cefamandole in the treatment of bone and joint infections is warranted.

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