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Immunity to Placental Malaria. II. Placental Antigen-Specific Cytokine Responses Are Impaired in Human Immunodeficiency Virus-Infected Women
Julie M. Moore, John Ayisi, Bernard L. Nahlen, Ambrose Misore, Altaf A. Lal and Venkatachalam Udhayakumar
The Journal of Infectious Diseases
Vol. 182, No. 3 (Sep., 2000), pp. 960-964
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30109306
Page Count: 5
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An association was demonstrated recently between elevated in vitro production of interferon (IFN)-γ by intervillous blood mononuclear cells (IVBMCs) and protection against placental malaria (PM). Because human immunodeficiency virus (HIV)-mfected pregnant women have increased susceptibility to PM, loss of the (IFN)-γ response in these women may impair their ability to control PM. Measurement of cytokines in culture supernatants by ELISA revealed that (IFN)-γ responses by HIV-positive IVBMCs were impaired, especially after malarial antigen stimulation. Interleukin (IL)-4 and IL-10 responses also were reduced in HIV-positive persons, the latter more so in HIV-positive, PM-positive persons. In contrast, tumor necrosis factor-α production generally was enhanced in PM-positive and HIV-positive persons. Overall, cytokine production was reduced in HIV-positive persons with CD4 T cell counts <500/µL, particularly in response to malarial antigen. Thus, HIV-mediated cytokine dysregulation and impairment of the protective (IFN)-γ response may contribute to the increased susceptibility of HIV-positive pregnant women to malaria.
The Journal of Infectious Diseases © 2000 Oxford University Press