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Immunologic Diagnosis of Legionnaires' Disease: Cross-Reactions with Anaerobic and Microaerophilic Organisms and Infections Caused by Them

P. H. Edelstein, R. M. McKinney, R. D. Meyer, M. A. C. Edelstein, C. J. Krause and S. M. Finegold
The Journal of Infectious Diseases
Vol. 141, No. 5 (May, 1980), pp. 652-655
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30109876
Page Count: 4
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Immunologic Diagnosis of Legionnaires' Disease: Cross-Reactions with Anaerobic and Microaerophilic Organisms and Infections Caused by Them
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Abstract

Three hundred twenty-four isolates of anaerobic and microaerophilic organisms were examined with a polyvalent direct immunofluorescent antibody (DFA) reagent directed against Legionella pneumophila, serogroups (SG) I-IV. Three of 53 isolates of Bacteroides fragilis cross-reacted with the SG I component of the reagent. Rabbit antisera to three SG I strains of L. pneumophila cross-reacted with these three B. fragilis isolates, and cross-reactivity was not due to preexisting rabbit antibodies; antisera to a fourth SG I strain did not cross-react with these isolates. Indirect fluorescent antibody (IFA) examinations of convalescent-phase sera from eight of 41 patients with B. fragilis group infections showed titers of ≥1:128 or a fourfold or greater seroconversion against L. pneumophila, SG I. All eight patients had bacteremia due to B. fragilis, but five B. fragilis isolates available from these patients were DFA-negative. Thus, false-positive reactions may result from DFA as well as IFA examinations of sera from patients with B. fragilis infections.

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