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Common Human T Cell Leukemia Virus Type 1 (HTLV-1) Integration Sites in Cerebrospinal Fluid and Blood Lymphocytes of Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Indicate that HTLV-1 Crosses the Blood-Brain Barrier via Clonal HTLV-1-Infected Cells

Marielle Cavrois, Antoine Gessain, Olivier Gout, Simon Wain-Hobson and Eric Wattel
The Journal of Infectious Diseases
Vol. 182, No. 4 (Oct., 2000), pp. 1044-1050
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30110077
Page Count: 7
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Common Human T Cell Leukemia Virus Type 1 (HTLV-1) Integration Sites in Cerebrospinal Fluid and Blood Lymphocytes of Patients with HTLV-1-Associated Myelopathy/Tropical Spastic Paraparesis Indicate that HTLV-1 Crosses the Blood-Brain Barrier via Clonal HTLV-1-Infected Cells
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Abstract

In the spinal cord of patients with human T cell leukemia virus type 1 (HTLV-1)-associated myelopathy/tropical spastic paraparesis (HAM/TSP), infiltrating CD4⁺ lymphocytes seem to be the major reservoir for the virus. Little, however, is known about the mechanisms by which HTLV-1 crosses the blood-brain barrier. An oligoclonal proliferation of HTLV-1-infected CD4 lymphoid T cells is present in the peripheral blood of all HTLV-1-infected individuals. Here, such oligoclonal distribution of HTLV-1-infected cells is evidenced in the cerebrospinal fluid (CSF) derived from 5 patients with HAM/TSP. Furthermore, clonal populations of HTLV-1-infected lymphocytes sharing the same HTLV-1 proviral flanking sequences (i.e., integration sites in the cellular DNA), and thus derived from a single HTLV-1-infected progenitor, were found, for a given patient, in both the CSF and the peripheral blood. These data demonstrate that HTLV-1 crosses the blood-brain barrier by migration of HTLV-1-infected lymphocytes in vivo.

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