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In vitro Resistance to Thrombin-Induced Platelet Microbicidal Protein in Isolates of Staphylococcus aureus from Endocarditis Patients Correlates with an Intravascular Device Source
Vance G. Fowler Jr., Lauren M. McIntyre, Michael R. Yeaman, Gail E. Peterson, L. Barth Reller, G. Ralph Corey, Dannah Wray and Arnold S. Bayer
The Journal of Infectious Diseases
Vol. 182, No. 4 (Oct., 2000), pp. 1251-1254
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30110107
Page Count: 4
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Platelet microbicidal proteins (PMPs) are small antimicrobial peptides secreted by mammalian platelets. In vitro resistance of Staphylococcus aureus strains to PMPs correlates with more extensive disease in experimental infective endocarditis (IE). To determine whether this same relationship exists in human S. aureus IE, we evaluated the in vitro PMP susceptibility phenotype of isolates from 58 prospectively-identified patients with definite S. aureus IE. On multivariate analyses, patients with S. aureus IE complicating an infected intravascular device were significantly more likely to have IE caused by a PMP-resistant strain (P = .0193). No correlations were detected between in vitro PMP resistance among S. aureus strains and the severity of human IE. This work supports the concept that in vitro PMP resistance in clinical S. aureus strains is associated with important clinical characteristics of S. aureus endovascular infections in vivo.
The Journal of Infectious Diseases © 2000 Oxford University Press