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Serum Antibody as a Marker of Protection against Natural Rotavirus Infection and Disease

F. Raúl Velázquez, David O. Matson, M. Lourdes Guerrero, Justine Shults, Juan J. Calva, Ardythe L. Morrow, Roger I. Glass, Larry K. Pickering and Guillermo M. Ruiz-Palacios
The Journal of Infectious Diseases
Vol. 182, No. 6 (Dec., 2000), pp. 1602-1609
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30110525
Page Count: 8
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Serum Antibody as a Marker of Protection against Natural Rotavirus Infection and Disease
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Abstract

To determine whether naturally acquired serum IgA and IgG antibodies were associated with protection against rotavirus infection and illness, a cohort of 200 Mexican infants was monitored weekly for rotavirus excretion and diarrhea from birth to age 2 years. Serum samples collected during the first week after birth and every 4 months were tested for antirotavirus IgA and IgG. Children with an IgA titer >1:800 had a lower risk of rotavirus infection (adjusted relative risk [aRR], 0.21; P<.001) and diarrhea (aRR, 0.16; P = .01) and were protected completely against moderate-to-severe diarrhea. However, children with an IgG titer >1:6400 were protected against rotavirus infection (aRR, 0.51; P < .001) but not against rotavirus diarrhea. Protective antibody titers were achieved after 2 consecutive symptomatic or asymptomatic rotavirus infections. These findings indicate that serum anti-rotavirus antibody, especially IgA, was a marker of protection against rotavirus infection and moderateto-severe diarrhea.

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