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Intrarenal Distribution of Ampicillin in the Normal and Diseased Human Kidney

Andrew Whelton, Daniel G. Sapir, Gordon G. Carter, Mary Ann Garth and W. Gordon Walker
The Journal of Infectious Diseases
Vol. 125, No. 5 (May, 1972), pp. 466-470
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30110871
Page Count: 5
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Intrarenal Distribution of Ampicillin in the Normal and Diseased Human Kidney
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Abstract

In the normal human kidney, the intrarenal tissue concentrations of ampicillin in the hydrated and hydropenic state demonstrate a pattern similar to that previously described for the kidney of the dog. The outer medullary and papillary concentrations, of presumed importance in the treatment of pyelonephritis, are uninfluenced by the state of hydration. In the severely diseased human kidney, a marked reduction in tissue penetration of the antibiotic is noted, and the ability of the kidney to concentrate ampicillin in the urine is greatly reduced. Levels in serum are almost twice as high as the levels in renal tissue. Studies of intrarenal distribution of ampicillin in the normal and diseased state should facilitate interpretation of tubedilution studies in the management of complicated renal infections.

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