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Immune Responses to Recombinant Proteins of Mycobacterium leprae

K. A. Wilkinson, K. Katoch, U. Sengupta, M. Singh, K. K. Sarin, J. Ivanyi and R. J. Wilkinson
The Journal of Infectious Diseases
Vol. 179, No. 4 (Apr., 1999), pp. 1034-1037
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30111828
Page Count: 4
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Immune Responses to Recombinant Proteins of Mycobacterium leprae
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Abstract

Identification of antigenic determinants of the polar immune response in leprosy may illuminate both protection and pathogenesis. Thirty subjects were studied (22 with polar disease and 8 healthy controls who were heavily exposed but disease-free) by assaying the proliferative, interferon (IFN)-γ, and antibody responses to recombinant antigens of Mycobacterium leprae (10, 28, 36, and 65 kDa). The 10-kDa antigen elicited IFN-γ production from all tuberculoid (TT) and borderline tuberculoid (BT) patients but little from controls, lepromatous (LL), or borderline lepromatous (BL) patients (P <.05). Production of 65-kDa-specific IFN-γ was higher in TT/BT than in controls or LL/BL patients (p <.006). All subjects produced 65kDa-specific antibody, but it was higher in LL/BL patients than in healthy controls, whose responses were higher than in TT/BT subjects (P = .035). The 36-kDa antibody responses were selectively increased in LL/BL subjects (P < .02). The intermediate phenotype of the controls suggests that M /eprae-specific production of IFN-γ may contribute to pathology and to protection in leprosy.

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