Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Demonstration of Chlamydia pneumoniae in Atherosclerotic Lesions of Coronary Arteries

Cho-chou Kuo, Allan Shor, Lee Ann Campbell, Hideto Fukushi, Dorothy L. Patton and J. Thomas Grayston
The Journal of Infectious Diseases
Vol. 167, No. 4 (Apr., 1993), pp. 841-849
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30112346
Page Count: 9
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Demonstration of Chlamydia pneumoniae in Atherosclerotic Lesions of Coronary Arteries
Preview not available

Abstract

Chlamydia pneumoniae is a human respiratory pathogen that causes acute respiratory disease and ∼ 10% of community-acquired pneumonia. The infections are geographically widespread. Antibody prevalence studies have shown that virtually everyone is infected with the C. pneumoniae organisms at some time and that reinfection is common. In addition to respiratory disease, seroepidemiologic studies have shown an association of this organism with coronary artery disease. C. pneumoniae was detected in coronary artery atheromas by immunocytochemistry (15/36) and by polymerase chain reaction (PCR) (13/30) in 20 of 36 autopsy cases from Johannesburg, South Africa. Sequence analysis of the C. pneumoniae rRNA genes amplified by PCR confirmed that the amplified gene products were C. pneumoniae. Electron microscopy revealed typical pear-shaped C. pneumoniae elementary bodies in 6 of 21 atheromatous plaques. These findings support the seroepidemiologic studies and offer further evidence that C. pneumoniae may be involved in the atherosclerotic process.

Page Thumbnails

  • Thumbnail: Page 
841
    841
  • Thumbnail: Page 
842
    842
  • Thumbnail: Page 
843
    843
  • Thumbnail: Page 
844
    844
  • Thumbnail: Page 
845
    845
  • Thumbnail: Page 
846
    846
  • Thumbnail: Page 
847
    847
  • Thumbnail: Page 
848
    848
  • Thumbnail: Page 
849
    849