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Demonstration of Chlamydia pneumoniae in Atherosclerotic Lesions of Coronary Arteries
Cho-chou Kuo, Allan Shor, Lee Ann Campbell, Hideto Fukushi, Dorothy L. Patton and J. Thomas Grayston
The Journal of Infectious Diseases
Vol. 167, No. 4 (Apr., 1993), pp. 841-849
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30112346
Page Count: 9
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Chlamydia pneumoniae is a human respiratory pathogen that causes acute respiratory disease and ∼ 10% of community-acquired pneumonia. The infections are geographically widespread. Antibody prevalence studies have shown that virtually everyone is infected with the C. pneumoniae organisms at some time and that reinfection is common. In addition to respiratory disease, seroepidemiologic studies have shown an association of this organism with coronary artery disease. C. pneumoniae was detected in coronary artery atheromas by immunocytochemistry (15/36) and by polymerase chain reaction (PCR) (13/30) in 20 of 36 autopsy cases from Johannesburg, South Africa. Sequence analysis of the C. pneumoniae rRNA genes amplified by PCR confirmed that the amplified gene products were C. pneumoniae. Electron microscopy revealed typical pear-shaped C. pneumoniae elementary bodies in 6 of 21 atheromatous plaques. These findings support the seroepidemiologic studies and offer further evidence that C. pneumoniae may be involved in the atherosclerotic process.
The Journal of Infectious Diseases © 1993 Oxford University Press