Access

You are not currently logged in.

Access JSTOR through your library or other institution:

login

Log in through your institution.

Journal Article

Adenovirus Infection in Pediatric Liver Transplant Recipients

Marian G. Michaels, Michael Green, Ellen R. Wald and Thomas E. Starzl
The Journal of Infectious Diseases
Vol. 165, No. 1 (Jan., 1992), pp. 170-174
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30112512
Page Count: 5
Were these topics helpful?
See somethings inaccurate? Let us know!

Select the topics that are inaccurate.

Cancel
  • Download ($42.00)
  • Subscribe ($19.50)
  • Add to My Lists
  • Cite this Item
Adenovirus Infection in Pediatric Liver Transplant Recipients
Preview not available

Abstract

A retrospective review of adenoviral infection in pediatric liver transplant recipients was done at Children's Hospital of Pittsburgh to define its epidemiology and clinical importance. Medical records of patients with adenovirus were reviewed and data collected regarding clinical course, microbiologic studies, biopsy results, immunosuppression, concurrent infections, and outcome. Of 484 liver transplant recipients, 49 had 53 episodes of adenoviral infection. The most common sites of adenoviral infection were the liver, lung, and gastrointestinal tract. Serotypes 1, 2, and 5 were recovered most often; type 5 was commonly associated with hepatitis. Invasive adenoviral infection occurred in 20 children, leading to death in 9. Median time from transplantation until isolation of adenovirus was 25.5 days. This timing suggests either reactivation or donor-associated transmission. Prospective studies using molecular epidemiologic techniques will be helpful in evaluating transmission patterns of adenovirus in this population.

Page Thumbnails

  • Thumbnail: Page 
170
    170
  • Thumbnail: Page 
171
    171
  • Thumbnail: Page 
172
    172
  • Thumbnail: Page 
173
    173
  • Thumbnail: Page 
174
    174