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Immune Responsiveness to the Immunodominant Recombinant Envelope Epitopes of Human T Lymphotropic Virus Types I and II in Diverse Geographic Populations

Cindy Buckner, Chester R. Roberts, Steven K. H. Foung, James Lipka, Gregory R. Reyes, Kenneth Hadlock, Lily Chan, Renan A. Gongora-Biachi, Brian Hjelle and Renu B. Lal
The Journal of Infectious Diseases
Vol. 166, No. 5 (Nov., 1992), pp. 1160-1163
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30113393
Page Count: 4
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Immune Responsiveness to the Immunodominant Recombinant Envelope Epitopes of Human T Lymphotropic Virus Types I and II in Diverse Geographic Populations
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Abstract

The heterogeneity of immune responsiveness to the immunodominant epitopes of human T lymphotropic virus (HTLV) types I (MTA-$1^{162-209}$) and II (K-$55^{162-205}$) were determined in natural infections with HTLV-I and -II from diverse geographic areas (n = 285). Of the HTLV-I specimens confirmed by polymerase chain reaction (PCR), all North American (n = 37) and Peruvian (n = 19) specimens reacted with MTA-1. Of HTLV-II specimens confirmed by PCR, 44 (96%) of 46 from North American blood donors, 28 (97%) of 29 from native Americans, and all from intravenous drug users (n = 29) reacted with K-55. Specimens from other geographic areas (Peru, 30; Brazil, 4; Mexico, 10; Italy, 5; Somalia, 13; Ethiopia, 17; Japan, 32; and Jamaica, 15) all reacted either with MTA-1 or K-55. By synthetic peptide-based serologic typing, all of these specimens could be typed as HTLV-I or -II. In addition to the direct implications of these findings for diagnostic purposes, these data provide indirect evidence for the conservation of immunodominant $HTLV_{env}$ epitopes in diverse geographic populations.

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