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Evidence of Previous Infection with Mycobacterium Avium-Mycobacterium Intracellulare Complex among Healthy Subjects: An International Study of Dominant Mycobacterial Skin Test Reactions

C. Fordham von Reyn, Thomas W. Barber, Robert D. Arbeit, Carol H. Sox, Gerald T. O'Connor, Richard J. Brindle, Charles F. Gilks, Rati Hakkarainen, Annamari Ranki, Courtenay Bartholomew, Jeffry Edwards, Anna N. S. Tosteson and Mogens Magnussom
The Journal of Infectious Diseases
Vol. 168, No. 6 (Dec., 1993), pp. 1553-1558
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30113715
Page Count: 6
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Evidence of Previous Infection with Mycobacterium Avium-Mycobacterium Intracellulare Complex among Healthy Subjects: An International Study of Dominant Mycobacterial Skin Test Reactions
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Abstract

Skin tests with 0.1 mL of intermediate-strength Mycobacterium tuberculosis purified protein derivative (PPD) and 0.1 mL of Mycobacterium avium sensitin were conducted on 484 healthy subjects from diverse geographic sites. Reactions of ^5 mm to one antigen that exceeded the reaction to the other by ^3 mm were considered M. aviumor PPD-dominant. PPD-dominant reactions were more frequent at sites where routine Bacille Calmette-Guerin immunization is done or where there are high rates of tuberculosis: New Hampshire, 207o; Boston, 70Zo; Finland, 1407o; Trinidad, 2607o; and Kenya, 2807o. However, rates of M. av/u/n-dominant reactions ranged from 70Zo to 1207o at all sites. Analysis of dominant reactions based on a more stringent 10-mm minimum reaction size showed similar trends. These data suggest that exposure to MAC is similar in developed and developing countries but that broad mycobacterial immunity is greater in developing countries and may contribute to the lower rates of disseminated MAC infections in AIDS in these areas.

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