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Apparent Selection against Transmission of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Variants

Johan Wahlberg, José Fiore, Gioacchino Angarano, Mathias Uhlén and Jan Albert
The Journal of Infectious Diseases
Vol. 169, No. 3 (Mar., 1994), pp. 611-614
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30113784
Page Count: 4
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Apparent Selection against Transmission of Zidovudine-Resistant Human Immunodeficiency Virus Type 1 Variants
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Abstract

The sexual transmission of zidovudine-resistant human immunodeficiency virus type 1 (HIV-1) variants was investigated in 5 donor-recipient pairs in which all donors and none of the recipients had received zidovudine treatment. The virus isolates were tested for sensitivity to zidovudine ($IC_50$) in vitro using blood donor lymphocytes. A region of the HIV-1 pol gene was also directly sequenced by a solid-phase sequencing method. Four donors were shown to have zidovudine-resistant HIV-1 variants. Two of these patients had a single mutation (Thr215➝Tyr), and 2 had a double mutation (Met41➝Leu and Thr215➝Tyr) that previously has been shown to confer zidovudine resistance. Zidovudine-resistant virus was found in only 1 of the 4 recipients, which indicates that zidovudine-resistant HIV-1 variants may be selected against during transmission. Thus, the transmission of zidovudine-resistant HIV-1 variants is a comples process that will require consideration whenever zidovudine treatment is initiation in persons who may have been infected by resistant variants.

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