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Correlation of Urinary Lactic Dehydrogenase with Polymorphonuclear Leukocytes in Urinary Tract Infections in Patients with Spinal Cord Injuries

Ghaus M. Malik, Hanna N. Canawati, Anthony J. Keyser, Maher Z. Ibrahim and John Z. Montgomerie
The Journal of Infectious Diseases
Vol. 147, No. 1 (Jan., 1983), p. 161
Published by: Oxford University Press
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Page Count: 1
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A number of indirect methods have been developed to determine the site of urinary tract infection, including the measurement of LDH in urine [1]. Although LDH has been thought to be from the kidneys, it has also been noted that leukocytes could contribute LDH isoenzymes 4 and 5 [2]. Seventeen patients with injured spinal cords and significant bacteriuria were included in this study. Urine specimens obtained by urethral catheter were cultured, and PMNLs identified with Sternheimer-Malbin stain were counted in a hemacytometer. A positive test for antibody-coated bacteria and the lack of patient response to five to 10 days of antibiotic therapy were used as an indication of upper urinary tract infection. Levels of LDH isoenzymes 4 and 5 (cathodal) correlated with the number of PMNLs in the urine (r = 0.63, P < 0.01). There was no correlation of PMNLs with LDH isoenzymes 1 and 2 (r = 0.18). In addition, there was no correlation of LDH isoenzymes 4 and 5 with the level of urinary tract infection. These results suggest that the PMNLs in the urine are the source of the LDH isoenzymes 4 and 5.

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