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Cvyptococcus neoformans and Candida albicans Regulate CD4 Expression on Human Monocytes

Donatella Pietrella, Claudia Monari, Cinzia Retini, Barbara Palazzetti, Thomas R. Kozel and Anna Vecchiarelli
The Journal of Infectious Diseases
Vol. 178, No. 5 (Nov., 1998), pp. 1464-1471
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30117374
Page Count: 8
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Cvyptococcus neoformans and Candida albicans Regulate CD4 Expression on Human Monocytes
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Abstract

This study examined the capability of Candida albicans and Cryptococcus neoformans to modulate CD4 expression on human monocytes. C. albicans and an acapsular strain of C. neoformans induced higher levels of CD4 expression than encapsulated strains. Purified glucuronoxylomannan did not regulate CD4 expression on monocytes, but down-regulation of CD4 expression compared with stimulation by acapsular C. neoformans alone was observed when glucuronoxylomannan was used in combination with acapsular C. neoformans. The ability of opsonic factors to facilitate fungal-mediated CD4 overexpression suggests that binding or internalization (or both) of the yeast cells is a critical event. Protein synthesis was required, excluding redistribution of the intracellular pool of CD4 receptors to the cellular surface as the sole possible mechanism. Results demonstrate a new effect of fungi on professional phagocytic cells and raise the possibility that modulation of CD4 could influence gpl20-mediated human immunodeficiency virus entry.

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