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Association of Human Papillomavirus Infection and Disease with Magnitude of Human Immunodeficiency Virus Type 1 (HIV-1) RNA Plasma Level among Women with HIV-1 Infection

Amneris E. Luque, Lisa M. Demeter and Richard C. Reichman
The Journal of Infectious Diseases
Vol. 179, No. 6 (Jun., 1999), pp. 1405-1409
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30117412
Page Count: 5
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Association of Human Papillomavirus Infection and Disease with Magnitude of Human Immunodeficiency Virus Type 1 (HIV-1) RNA Plasma Level among Women with HIV-1 Infection
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Abstract

Ninety-three women with human immunodeficiency virus type 1 (HIV-1) infection were enrolled in a cross-sectional study to evaluate the relationship between plasma HIV-1 RNA levels and coincident cervical infection and disease caused by human papillomaviruses (HPVs). HIV-1 RNA plasma levels of >10,000 copies/mL were highly associated with the presence in cervical specimens of HPV DNA of oncogenic (high risk) virus genotypes (P = .006; relative risk, 2.57). In addition, similar HIV-1 RNA plasma levels were associated with abnormal Pap smears (P = .01; relative risk, 2.11). In this study, 81% of women with high-risk HPV cervical infection had abnormal Pap smears. Measurement of HIV-1 RNA plasma levels may help to identify a subgroup of HIV-1-infected women at increased risk for cervical HPV infection and disease.

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