Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Bacteria-Specific Antibody in the Urine of Patients with Acute Pyelonephritis and Cystitis

Joan J. Ratner, Virginia L. Thomas, Barbara A. Sanford and Marvin Forland
The Journal of Infectious Diseases
Vol. 143, No. 3 (Mar., 1981), pp. 404-412
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30119479
Page Count: 9
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Bacteria-Specific Antibody in the Urine of Patients with Acute Pyelonephritis and Cystitis
Preview not available

Abstract

Urine specimens from 65 adult patients with symptomatic urinary tract infections that involved 91 episodes of well-defined acute pyelonephritis or cystitis were tested for antibody-coated bacteria (ACB) by a fluorescent antibody assay, unbound bacteria-specific antibody by radioimmunoassay (RIA), and levels of total protein and IgG. Acute pyelonephritis was associated with positive tests for ACB (22 [69%] of 32), elevated levels of unbound antibody (28 [88%] of 32), and a mean RIA binding ratio of 9.4. Cystitis was associated with negative tests for ACB (56 [95%] of 59), low levels of antibody in urine (38 [64%] of 59), and a mean RIA binding ratio of 3.2. The results showed that a negative test for ACB may occur with elevated levels of unbound antibody in the urine because, although elevated, levels were still too low to result in detectable antibody coating of the bacteria. There was often, but not always, a correlation between RIA binding ratios and levels of urinary protein and IgG.

Page Thumbnails

  • Thumbnail: Page 
404
    404
  • Thumbnail: Page 
405
    405
  • Thumbnail: Page 
406
    406
  • Thumbnail: Page 
407
    407
  • Thumbnail: Page 
408
    408
  • Thumbnail: Page 
409
    409
  • Thumbnail: Page 
410
    410
  • Thumbnail: Page 
411
    411
  • Thumbnail: Page 
412
    412