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Antiborrelial Activity of Serum from Rats Injected with the Lyme Disease Spirochete
Charles S. Pavia, Vincent Kissel, Susan Bittker, Felipe Cabello and Seymour Levine
The Journal of Infectious Diseases
Vol. 163, No. 3 (Mar., 1991), pp. 656-659
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30123186
Page Count: 4
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The functional properties of humoral factors generated in rats immunized against Borrelia burgdorferi were investigated. After Lewis strain rats were injected intraperitoneally with live B. burgdorferi or in the footpad with dead borreliae incorporated in complete Freund's adjuvant, they produced high-titered antisera. At a dilution of ≤1:10, sera from immunized or infected rats but not control sera inhibited growth of B. burgdorferi in vitro. Neutralization of growth of three different strains of B. burgdorferi by posttreatment sera was dose-dependent and was detected equally well by direct microscopic counts or by measuring incorporation of tritiated adenine into newly synthesized nucleic acids. These findings provide direct evidence that infection or immunization with the Lyme disease spirochete induces the formation of serum factors capable of preventing the growth of B. burgdorferi in vitro.
The Journal of Infectious Diseases © 1991 Oxford University Press