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A Dose-Ranging Study of a Prototype Synthetic HIV-$1_{MN}$ V3 Branched Peptide Vaccine

Geoffrey J. Gorse, Michael C. Keefer, Robert B. Belshe, Thomas J. Matthews, Bruce D. Forrest, Ray-Hahn Hsieh, Wayne C. Koff, Carl V. Hanson, Raphael Dolin, Kent J. Weinhold, Sharon E. Frey, Nzeera Ketter and Patricia E. Fast
The Journal of Infectious Diseases
Vol. 173, No. 2 (Feb., 1996), pp. 330-339
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30126127
Page Count: 10
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A Dose-Ranging Study of a Prototype Synthetic HIV-$1_{MN}$ V3 Branched Peptide Vaccine
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Abstract

A phase I double-blind trial was done to examine the safety and immunogenicity of a prototype synthetic human immunodeficiency virus type 1 MN strain (HIV-$1^{MN}$) third variable region domain (V3) branched peptide vaccine in HIV-1-uninfected healthy adult volunteers. Subjects were randomly assigned to receive 20, 100, or 500 µg of vaccine or alum adjuvant control on days 0, 28, and 168. The vaccine was well-tolerated and appeared safe. Induction of binding antibody to V3 MN branched peptide was vaccine dose-related and was detectable in 9 of 10 subjects in the highestvaccine-dose group. HIV-$1^{MN}$-neutralizing antibody was detected after the third 500-µg dose in 8 of 10 subjects at the 90% neutralization end point. V3 MN peptide stimulated lymphocyte proliferation in 15 (75%) of 20 subjects after vaccination. In conclusion, this prototype vaccine was safe and it induced humoral and cell-mediated immune responses.

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