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Interleukin-7 Induces Anti-Mycobacterium avium Activity in Human Monocyte-Derived Macrophages

Terapong Tantawichien, Lowell S. Young and Luiz E. Bermudez
The Journal of Infectious Diseases
Vol. 174, No. 3 (Sep., 1996), pp. 574-582
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30128202
Page Count: 9
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Interleukin-7 Induces Anti-Mycobacterium avium Activity in Human Monocyte-Derived Macrophages
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Abstract

To examine the modulatory role of interleukin (IL)-7 on intracellular growth of Mycobacterium avium complex (MAC), human macrophages were treated either before or after MAC infection with different concentrations of IL-7. At 100 pg/mL, 1 ng/mL, and 10 ng/mL, treatment with IL-7 before infection stimulated secretion of tumor necrosis factor-α (TNF-α) from MAC-infected macrophages (increase up to 40%) and resulted in dose-dependent reduction in the number of intracellular bacteria. Pretreatment with IL-7 did not inhibit the secretion of transforming growth factor-β₁ (TGF-β₁). IL-7 added to the macrophage monolayer 4 h after infection resulted in both the secretion of TNF-± from MAC-infected macrophages (up to 90% increase, P < .05) and antimycobacterial activity (up to 50% reduction in bacteria, P < .05); however, TGF-β₁ production was not inhibited. IL-7-dependent anti-MAC activity of macrophages was inhibited by anti-human TNF-α antibody. These results suggest that IL-7 may contribute to the regulation of the immune response against MAC.

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