You are not currently logged in.
Access JSTOR through your library or other institution:
Localization of Chronic Chlamydia psittaci Infection in the Reproductive Tract of Sheep
John R. Papp and Patricia E. Shewen
The Journal of Infectious Diseases
Vol. 174, No. 6 (Dec., 1996), pp. 1296-1302
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30129961
Page Count: 7
You can always find the topics here!Topics: Infections, Reproductive tract infections, Ewes, Oviducts, Polymerase chain reaction, Uterus, Pregnancy, Sheep, Vagina, Plasma cells
Were these topics helpful?See something inaccurate? Let us know!
Select the topics that are inaccurate.
Preview not available
Twelve sheep experimentally infected with Chlamydia psittaci during pregnancy either aborted or gave birth to weak, low-birth-weight lambs as a result of uteroplacental infection. Subsequently, these ewes excreted chlamydial antigen from their reproductive tracts during estrus. About 1 year after pregnancy failure, immunohistochemistry and polymerase chain reaction were used to examine sections of vagina, uterus, and oviduct for evidence of C. psittaci. Four noninfected control ewes were similarly examined. C. psittaci antigen or DNA was detected in vagina, uterus, and oviduct samples from chronically infected ewes. Endometrial cells in the basal stroma were the predominant site of infection. There was no obvious evidence of pathology associated with persistent infection, but increased numbers of plasma cells and intraepithelial lymphocytes were detected in the uterus. C. psittaci is a naturally occurring reproductive infection in sheep that persists following primary infection. Therefore, sheep provide an excellent model to study the host-parasite interactions that occur during natural infection and subsequent persistence.
The Journal of Infectious Diseases © 1996 Oxford University Press