Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

The Kinetics of Early Inflammatory Events during Experimental Pneumonia Due to Legionella pneumophila in Guinea Pigs

Gerald S. Davis, Washington C. Winn Jr., Dieter W. Gump and Harry N. Beaty
The Journal of Infectious Diseases
Vol. 148, No. 5 (Nov., 1983), pp. 823-835
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30131419
Page Count: 13
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
The Kinetics of Early Inflammatory Events during Experimental Pneumonia Due to Legionella pneumophila in Guinea Pigs
Preview not available

Abstract

An animal model of Legionella pneumophila pneumonia was developed to study aerosol infection, pathogenesis, and pulmonary host defense mechanisms. Guinea pigs were exposed in an inhalation facility that limited the aerosol of L pneumophila to the snout. Bronchoalveolar lavage was used to sample airspace cells, secretions, and bacteria during developing infection in 79 exposed animals and 13 uninfected controls. An influx of polymorphonuclear neutrophils followed exponential bacterial growth during the initial three days of infection and coincided with limitation of the increase in bacteria recovered. A macrophage influx occurred at three to five days. Bacteria were eliminated from the lung by 11 days after exposure. Albumin in lavage fluid peaked at two days. Most viable L pneumophila organisms were associated with alveolar macrophages, whereas most of the bacteria associated with polymorphonuclear neutrophils were nonviable. Recruited, and possibly immune, defenses appear to be required for successful resolution of legionella pneumonia.

Page Thumbnails

  • Thumbnail: Page 
823
    823
  • Thumbnail: Page 
824
    824
  • Thumbnail: Page 
825
    825
  • Thumbnail: Page 
826
    826
  • Thumbnail: Page 
827
    827
  • Thumbnail: Page 
828
    828
  • Thumbnail: Page 
829
    829
  • Thumbnail: Page 
830
    830
  • Thumbnail: Page 
831
    831
  • Thumbnail: Page 
832
    832
  • Thumbnail: Page 
833
    833
  • Thumbnail: Page 
834
    834
  • Thumbnail: Page 
835
    835