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Characterization of Canine Humoral Immune Responses to Outer Surface Protein Subunit Vaccines and to Natural Infection by Lyme Disease Spirochetes

Jianneng Ma, Patrice A. Bulger, Suzanne Dante, Deborah v. R. Davis, Barbara Perilli-Palmer and Richard T. Coughlin
The Journal of Infectious Diseases
Vol. 171, No. 4 (Apr., 1995), pp. 909-915
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30132180
Page Count: 7
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Characterization of Canine Humoral Immune Responses to Outer Surface Protein Subunit Vaccines and to Natural Infection by Lyme Disease Spirochetes
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Abstract

Canine antibody responses to Lyme disease subunit vaccines and to natural borrelial infection were investigated. Vaccines were formulated with QS21 and outer surface proteins A (OspA) and B (OspB) derived from Borrelia burgdorferi B31. Vaccines containing QS21 and the lipoproteins gave 4-fold higher IgGl and 8-fold higher IgG2 antibody responses than without QS21. Antisera to lipidated OspA or OspB vaccines containing QS21 had high antiborrelial activity against isolates B31 and CA-2-87, similar to those with a vaccine containing both OspA and OspB. Only the combination vaccine induced antiborrelial activity against heterologous isolates 24008 Fr and Borrelia garinii G25. Nonlipidated OspAand OspB-based vaccines with QS21 elicited lower antibody and antiborrelial activity than did lipidated OspA and OspB vaccines; 49% of naturally exposed dogs had low titers to OspA or OspB. Thus, vaccines using lipidated OspA, OspB, and QS21 could induce higher antiborrelial activity than did natural exposure.

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