Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Antigenic and Genomic Diversity within Group A Respiratory Syncytial Virus

Gregory A. Storch, Larry J. Anderson, Chung S. Park, Cecilia Tsou and Dennis E. Dohner
The Journal of Infectious Diseases
Vol. 163, No. 4 (Apr., 1991), pp. 858-861
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30132337
Page Count: 4
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Antigenic and Genomic Diversity within Group A Respiratory Syncytial Virus
Preview not available

Abstract

Antigenic analysis using monoclonal antibodies and genomic analysis using ribonuclease protection was done on 47 isolates of group a respiratory syncytial virus (RSV) recovered from children in St. Louis during four RSV seasons. Antigenic analysis identified four subgroups; of the three that included more than one member, those designated A/2 and A/$2_v$ had characteristic ribonuclease protection patterns. a third subgroup, A/4, exhibited more extensive genomic heterogeneity, but all isolates were distinguishable from those in subgroups A/2 and A/$2_v$. Individual RSV epidemic seasons included isolates representing multiple subgroups of group a and multiple intrasubgroup variants, in addition to isolates from group B. Isolates that were indistinguishable by either antigenic or genomic analysis were present in more than one epidemic season. The subgroups may represent parallel evolutionary lineages, whose relevance to RSV immunity and pathogenesis requires further study.

Page Thumbnails

  • Thumbnail: Page 
858
    858
  • Thumbnail: Page 
859
    859
  • Thumbnail: Page 
860
    860
  • Thumbnail: Page 
861
    861