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Comparison of Spinal Fluid β2-microglobulin Levels with CD4⁺ T Cell Count, in Vitro T Helper Cell Function, and Spinal Fluid IgG Parameters in 163 Neurologically Normal Adults Infected with the Human Immunodeficiency Virus Type 1

Daniel R. Lucey, Stephen A. McGuire, Mario Clerici, Kevin Hall, Jean Benton, Clifford A. Butzin, William W. Ward, Gene Shearer, R. Neal Boswell and Craig W. Hendrix
The Journal of Infectious Diseases
Vol. 163, No. 5 (May, 1991), pp. 971-975
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30132486
Page Count: 5
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Comparison of Spinal Fluid β2-microglobulin Levels with CD4⁺ T Cell Count, in Vitro T Helper Cell Function, and Spinal Fluid IgG Parameters in 163 Neurologically Normal Adults Infected with the Human Immunodeficiency Virus Type 1
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Abstract

β₂-microglobulin levels were measured in the cerebrospinal fluid (CSF) and serum of 163 human immunodeficiency virus-positive (HIV⁺) persons with normal neurologic physical examinations. None were on antiretroviral therapy. Only 3% had a positive CSF HIV p24 antigen test. The CSF β₂-microglobulin levels increased as the CD4⁺ T cell count decreased. Intrathecal production of β₂-microglobulin was suggested by finding CSF concentrations greater than serum concentrations in 15 % of patients. The CSF β₂-microglobulin levels rose as in vitro T helper cell function deteriorated, independent of CD4⁺ T cell count. CSF β₂-microglobulin levels paralleled CSF IgG, IgG index, and IgG synthesis. Higher CSF β₂-microglobulin levels were found in persons with positive CSF oligoclonal bands. CSF β₂-microglobulin concentration may serve as a marker for subclinical neurologic damage due to HIV. If this is established, defining the effect of anti-HIV interventions on CSF β₂-microglobulin would be warranted.

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