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Diagnosis of Pneumonia by Cultures, Bacterial and Viral Antigen Detection Tests, and Serology with Special Reference to Antibodies against Pneumococcal Antigens
Lars Å. Burman, Birger Trollfors, Bengt Andersson, Jörgen Henrichsen, Per Juto, Ingegerd Kallings, Teresa Lagergård, Roland Möllby and Ragnar Norrby
The Journal of Infectious Diseases
Vol. 163, No. 5 (May, 1991), pp. 1087-1093
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30132503
Page Count: 7
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In a prospective study of the etiology of pneumonia 196 adult patients were included. One of the following criteria was required for diagnosis of pneumococcal pneumonia: isolation of pneumococci from blood; isolation from transtracheal aspirate; isolation from sputum or nasopharynx or detection of capsular antigen in sputum in combination with a significant increase in antibodies against at least one pneumococcal antigen (type-specific capsular polysaccharide, C-polysaccharide, pneumolysin); or increase in antibodies against two pneumococcal antigens. Pneumococcal pneumonia was diagnosed in 63 patients (32%). Other diagnoses were nonencapsulated Haemophilus influenzae isolated from transtracheal aspirates, 9; Mycoplasma pneumoniae diagnosed by serology, 17; Chlamydia psittaci, 6; and viral infections, 42. Twenty-two patients (11%) had evidence of infection with more than one agent. The pathogen could not be determined in 70 (36%). Many patients were given antibiotics before admittance to the study, and in some cases a convalescent serum sample was not available.
The Journal of Infectious Diseases © 1991 Oxford University Press