Access

You are not currently logged in.

Access your personal account or get JSTOR access through your library or other institution:

login

Log in to your personal account or through your institution.

Immunosuppression in Paracoccidioidomycosis: T Cell Hyporesponsiveness to Two Paracoccidioides brasiliensis Glycoproteins That Elicit Strong Humoral Immune Response

Gil Benard, Maria José S. Mendes-Giannini, Michelangelo Juvenale, Elaine T. Miranda and Alberto J. S. Duarte
The Journal of Infectious Diseases
Vol. 175, No. 5 (May, 1997), pp. 1263-1267
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30132664
Page Count: 5
  • Download ($42.00)
  • Subscribe ($19.50)
  • Cite this Item
Immunosuppression in Paracoccidioidomycosis: T Cell Hyporesponsiveness to Two Paracoccidioides brasiliensis Glycoproteins That Elicit Strong Humoral Immune Response
Preview not available

Abstract

To assess human cellular immune response to paracoccidioidomycosis (PCM), lymphocyte proliferative responses to purified antigens from Paracoccidioides brasiliensis were determined in healthy persons previously infected by the fungus (positive donors), in healthy noninfected persons (controls), and in PCM patients. Affinity-purified gp70 and gp43, the two major antigens in humoral immune responses, were used. Both induced lymphocyte proliferation (gp43 species-specific) in positive donors but not in controls; healthy persons previously infected by Histoplasma capsulatum reacted to gp70 and not to gp43. A similar cross-reactivity in antibody response to gp70 was previously reported; however, antibody response to gp43 has been considered specific. Lymphocytes from PCM patients, who, unlike positive donors, have high levels of anti-gp43 and anti-gp70 antibodies, proliferated poorly with gp70 and gp43 but better with other stimuli. This dichotomy between humoral and cellular antigen-specific responses suggests a Th2 immune response in PCM, which may be related to failure to control the infection.

Page Thumbnails

  • Thumbnail: Page 
1263
    1263
  • Thumbnail: Page 
1264
    1264
  • Thumbnail: Page 
1265
    1265
  • Thumbnail: Page 
1266
    1266
  • Thumbnail: Page 
1267
    1267