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Histone Deacetylase Inhibitors Protect against and Mitigate the Lethality of Total-Body Irradiation in Mice
Stephen L. Brown, Andrew Kolozsvary, Jianguo Liu, Samuel Ryu and Jae Ho Kim
Vol. 169, No. 4 (Apr., 2008), pp. 474-478
Published by: Radiation Research Society
Stable URL: http://www.jstor.org/stable/30132984
Page Count: 5
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It was hypothesized that histone deacetylase (HDAC) inhibitors may increase survival after total-body irradiation (TBI) based on previous reports demonstrating that HDAC inhibitors stimulate the proliferation of bone marrow stem cells. Using the time for mice to lose 20% or more of their weight as the end point, two HDAC inhibitors, valproic acid and trichostatin-A, were found to reduce lethality in a dose-dependent manner. HDAC inhibitors were effective at reducing lethality when given either 24 h before or 1 h after TBI. The results indicate that HDAC inhibitors have potential for protecting against and mitigating radiation-induced lethality.
Radiation Research © 2008 Radiation Research Society