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Human Immunodeficiency Virus (HlV)-Infected Human Blood Monocytes and Peritoneal Macrophages Have Reduced Anticryptococcal Activity whereas HIV-infected Alveolar Macrophages Retain Normal Activity

Miriam L. Cameron, Donald L. Granger, Thomas J. Matthews and J. Brice Weinberg
The Journal of Infectious Diseases
Vol. 170, No. 1 (Jul., 1994), pp. 60-67
Published by: Oxford University Press
Stable URL: http://www.jstor.org/stable/30133475
Page Count: 8
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Human Immunodeficiency Virus (HlV)-Infected Human Blood Monocytes and Peritoneal Macrophages Have Reduced Anticryptococcal Activity whereas HIV-infected Alveolar Macrophages Retain Normal Activity
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Abstract

Human immunodeficiency virus type 1 (HIV-1) infection causes immune dysfunction. Mono-nuclear phagocytes (MNP) are immune effector cells against some intracellular pathogens and reservoirs for HIV-1. This study determined effects of HIV-1 on MNP-mediated antifungal function. MNP from seronegative volunteers were inoculated with $HIV_Bal$ or $HIV_IIIB.$ MNP were infected with an avirulent clone of Cryptococcus neoformans; 48 h later, MNP were lysed and yeasts were counted. Viral replication was determined by reverse transcriptase and by visualization of cytopathic effects. Monocytes and peritoneal macrophages exhibited reduced anticrypto-coccal activity 14 days after infection with $HIV_Baj$ but retained normal activity when infected with $HIV_hib.$ Loss of anticryptococcal activity correlated with viral replication. Alveolar macrophages retained normal anticryptococcal activity whether infected with $HIV_Bal$ or $HIV_IIIB.$ In vitro MNP-mediated antifungal activity may be altered by HIV-1 infection; this altered activity appears to depend on viral tropism, viral replication, and MNP tissue origin.

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